Driving the Commercialization of University of Chicago Research

Building on University of Chicago’s breakthroughs

Harper Court Ventures invests in transformative technologies emerging from the University of Chicago—where world-class research fuels real-world ventures. We back pre-seed startups at the frontier of quantum computing, life sciences, energy, and AI—spun out of university labs, accelerated by the Polsky Center, or founded by University of Chicago alumni. Led by Chicago Booth alum, Karthee Madasamy and managed by MFV Partners, a leading Silicon Valley deep tech fund, we’re building a new engine of innovation for the Midwest—and beyond.

Driving the Midwest’s deep tech future.

ENERGY

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QUANTUM COMPUTING

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LIFE SCIENCES

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AI / DATA SCIENCES

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LIFE SCIENCES​

QUANTUM COMPUTING​

ENERGY

AI / DATA SCIENCES​

Team

Our team brings together seasoned investors, technologists, and founders with decades of experience in scaling breakthrough innovation. From Silicon Valley to Chicago, we back visionary startups with the insight and support needed to lead in quantum, AI, life sciences, and energy.

Karthee Madasamy

Managing Partner

University of Chicago Booth alum and veteran deep tech investor with a track record in quantum, AI, energy, and robotics.

Portfolio

We invest in bold, early-stage startups emerging from the University of Chicago ecosystem. Each company in our portfolio is built on transformative research and positioned to lead in quantum, AI, life sciences, or energy.

Flow Medical

Health, Life Sciences

2024

SimCare

AI, Life Sciences

2025

Beacon

Health, Life Sciences

2025

News & Insights

Explore the latest announcements, founder stories, and deep tech trends shaping our work. Stay informed on how Harper Court Ventures and our portfolio companies are driving innovation forward.

Harper Court Ventures Launches with $25 Million Supporting University of Chicago Deep Tech Startups

Independently managed by MFV Partners, Fund I will back groundbreaking ventures emerging from the University of Chicago ecosystem.

Chicago has positioned itself to become a superstar hub for quantum computing

Chicago is emerging as a national leader in quantum computing, driven by world-class research institutions, public-private partnerships, and strong state support. With major investments, a deep talent pipeline, and startups

The Last Mile of EV Innovation: The Powertrain

Batteries have owned the public’s mind share when it comes to boosting performance and decreasing the cost of electric vehicles. And for good reason. The battery accounts for roughly half

Robotics Re-born: Why AI Will Usher in a Third Generation of ‘Humanoid’ Robots in 2025

TESLA‘s unveiling of its Optimus robot in October was met with a rightful dose of skepticism, as many of the capabilities the robots demonstrated were found to be powered by